Wide-field cortical imaging

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mini-mScope

Objective Biotechnology’s mini-mScope enables whole brain imaging in freely behaving rodents:

  • Image a wide field of view: up to 8mm x 10 mm of the dorsal cortex

  • 17 micron resolution

  • Pair functional imaging experiments in with behavioral measurements

mini-mScope in action

Neural activity

Open-field behavior of mouse bearing mini-mScope

Publications:

  1. M. L. Rynes*, D. Surinach*, S. Linn, M. Laroque, V. Rajendran, J. Dominguez, O. Hadjistamoulou, Z. S. Navabi, L. Ghanbari, G. W. Johnson, M. Nazari, M. Mohajerani, S. B. Kodandaramaiah, ‘Miniaturized head-mounted device for whole cortex mesoscale imaging in freely behaving mice’, Nature Methods 2021 *Equal Contribution

  2. Daniel Surinach,* Mathew L Rynes,* Kapil Saxena, Eunsong Ko, A David Redish, Suhasa B Kodandaramaiah, ‘Distinct mesoscale cortical dynamics encode search strategies during spatial navigation’, bioRxiv, March 2023, *Equal Contribution