Long-Term Optical Access to the Brain
See-Shells
Objective Biotechnology’s See-Shells enable long-term optical access to the rodent brain:
Transparent wide-field and cellular image access to the dorsal cortex
Customized designs for headfixed imaging and imaging with mini-mScope
Perforated See-Shells allow multi-modal neural interfacing
See-Shells in action
Two-photon imaging during wake head-fixation
Two-photo cortical column imaging
L. Ghanbari, R. E. Carter, M. L. Rynes, J. Dominguez, G. Chen, A. Naik, J. Hu, M. A. K. Sagar, L. Haltom, N. Mossazghi, M. M. Gray, S. L. West, K. W. Eliceiri, T. J. Ebner, S. B. Kodandaramaiah, ‘Cortex-wide neural interfacing via transparent polymer skulls’, Nature Communications’, 2019